THC, CBD, urumogi, ingaruka zo mu mutwe - ushobora kuba warigeze kumva byibuze bibiri muri aya magambo niba wagerageje kumva THC, CBD, nibitandukaniro hagati yabo. Birashoboka ko wanahuye na sisitemu ya endocannabinoid, reseptor ya urumogi, ndetse na terpene. Ariko mubyukuri mubyukuri?
Niba ushaka uburyo bwo gusobanukirwa impamvu ibicuruzwa bya THC bikugeza hejuru kandi ibicuruzwa bya CBD ntibikora nicyo bifitanye isano na endocannabinoide, ikaze, uri ahantu heza.
Urumogi n'uruhare rwa ECS
Kugira ngo usobanukirwe na THC vs CBD nuburyo bitugiraho ingaruka, ugomba kubanza gusobanukirwa na sisitemu ya endocannabinoid (ECS), ifasha umubiri kugumana uburinganire bwimikorere binyuze mubice bitatu byingenzi: molekile "intumwa", cyangwa endocannabinoide, umubiri wacu ukora; reseptors izo molekile zihuza; n'imisemburo ibacika.
Ububabare, guhangayika, ubushake bwo kurya, imbaraga za metabolisme, imikorere yumutima nimiyoboro y'amaraso, ibihembo no kubitera imbaraga, kubyara, no gusinzira ni bike mubikorwa byumubiri bigira urumogi bigira ingaruka kuri ECS. Ibyiza byubuzima bwurumogi ni byinshi kandi birimo kugabanya umuriro no kurwanya isesemi.
Ibyo THC ikora
Urumogi rwinshi kandi ruzwi cyane ruboneka mu gihingwa cy'urumogi ni tetrahydrocannabinol (THC). Ikora reseptor ya CB1, igice cya ECS mubwonko bugenga ubusinzi. Ubusinzi bwa THC bwagaragaye ko bwongera umuvuduko wamaraso kuri cortex ibanza, akarere k'ubwonko gashinzwe gufata ibyemezo, kwitondera, ubumenyi bwimodoka, nibindi bikorwa byubuyobozi. Imiterere nyayo yingaruka za THC kuriyi mikorere iratandukanye kubantu.
Iyo THC ihujwe na reseptor ya CB1, itera kandi ibyiyumvo bya euphoria biva muburyo bwo guhemba ubwonko. Urumogi rutangiza inzira yo guhemba ubwonko, bigatuma twumva tumerewe neza, kandi bikongerera amahirwe yo kongera kurya mugihe kizaza. Ingaruka za THC kuri sisitemu yo guhemba ubwonko nikintu gikomeye mubushobozi bwurumogi kubyara ibyiyumvo byubusinzi na euphoria.
Ibyo CBD ikora
THC iri kure yibintu byonyine bigize urumogi bigira ingaruka zitaziguye kumikorere yubwonko. Ikigereranyo kigaragara cyane ni urumogi (CBD), ni urwa kabiri urumogi rwinshi ruboneka mu gihingwa cy'urumogi. CBD ikunze kuvugwa ko idafite imitekerereze ariko ibi birayobya kuko ikintu cyose kigira ingaruka itaziguye kumikorere yubwonko ni psychoactive. CBD rwose itera ingaruka zo mumitekerereze iyo ikorana nubwonko na sisitemu yo hagati yo hagati, kuko bivugwa ko ifite imbaraga zikomeye zo kurwanya no gufata no kurwanya amaganya.
Mugihe rero CBD mubyukuri ari psychoactive, ntabwo isindisha. Ni ukuvuga, ntabwo igushira hejuru. Ibyo biterwa nuko CBD ari mbi cyane mugukora reseptor ya CB1. Mubyukuri, ibimenyetso byerekana ko mubyukuri bibangamira ibikorwa bya reseptor ya CB1, cyane cyane imbere ya THC. Iyo THC na CBD bakoranye kugirango bigire ingaruka kubikorwa bya reseptor ya CB1, abayikoresha bakunda kumva boroheje, bafite hejuru kandi bafite amahirwe make yo guhura na paranoia ugereranije ningaruka zagaragaye mugihe CBD idahari. Ibyo biterwa nuko THC ikora reseptor ya CB1, mugihe CBD irabuza.
Uburyo CBD na THC bakorana
Mu magambo make, CBD irashobora kurinda ubumuga bwo kutamenya bujyanye no gukabya gukabije kuri THC. Ubushakashatsi bwakozwe mu mwaka wa 2013 bwasohotse mu kinyamakuru cya Psychopharmacology bwahaye THC abitabiriye amahugurwa maze busanga abahawe CBD mbere y’ubuyobozi bwa THC bagaragaje ubumuga buke bwo mu mutwe kurusha abarwayi bari bahawe umwanya - bikomeza byerekana ko CBD ishobora gukumira ubwenge bwa THC buterwa na THC. deficits.
Mubyukuri, mu mwaka wa 2013 ubushakashatsi bwakozwe ku bushakashatsi bugera ku 1300 bwasohotse mu binyamakuru bya siyansi bwerekanye ko “CBD ishobora kurwanya ingaruka mbi za THC.” Isubiramo ryerekana kandi ko hakenewe ubushakashatsi bwinshi no kureba ingaruka za CBD ku mikoreshereze ya THC mu bihe nyabyo. Ariko amakuru ariho arasobanutse bihagije ko CBD ikunze gusabwa nkumuti urwanya abarya THC batabishaka kandi ugasanga barengewe.
Urumogi rukorana na sisitemu nyinshi mumubiri
THC na CBD bihuza izindi ntego nyinshi mumubiri. CBD, kurugero, ifite byibuze 12 yibikorwa byubwonko. Kandi aho CBD ishobora kuringaniza ingaruka za THC binyuze mukubuza kwakira CB1, birashobora kugira izindi ngaruka kuri metabolism ya THC kurubuga rutandukanye.
Nkigisubizo, CBD ntishobora guhora ibuza cyangwa kuringaniza ingaruka za THC. Irashobora kandi kuzamura mu buryo butaziguye inyungu nziza zubuvuzi. CBD irashobora, kurugero, kuzamura THC iterwa no kugabanya ububabare. THC irashobora kuba anti-inflammatory na neuroprotective antioxidant, ahanini biterwa nuko ikora reseptors ya CB1 ahantu hagenzura ububabare bwubwonko.
Ubushakashatsi bwakozwe mu mwaka wa 2012 bwerekanye ko CBD ikorana na alpha-3 (α3) ya reseptor ya glycine, intego ikomeye yo gutunganya ububabare mu ruti rw'umugongo, kugira ngo ihoshe ububabare budakira no gutwika. Nintangarugero mubyo bita ingaruka ya entourage, aho urumogi rutandukanye rukorera hamwe muri rusange kugirango rutange ingaruka zikomeye kuruta iyo zikoreshejwe ukwe.
Ariko n'iyi mikoranire ntabwo isobanutse neza. Mu bushakashatsi bwakozwe muri Gashyantare 2019, abashakashatsi basanze ibipimo bike bya CBD byongereye ingaruka mbi za THC, mu gihe dosiye nyinshi za CBD zagabanije ingaruka z’ubusinzi bwa THC.
Terpene n'ingaruka zoherekeza
Birashoboka rwose ko zimwe mu ngaruka z'urumogi zizwi cyane (nka couch-lock) zishobora kuba zidafite aho zihuriye na THC ubwazo, ahubwo, umusanzu ugereranije na molekile itazwi. Imiti yimiti yitwa terpene itanga ibihingwa byurumogi uburyohe bwihariye nimpumuro nziza. Biboneka mu bimera byinshi - nka lavender, igishishwa cyibiti, na hops - kandi bitanga impumuro yamavuta yingenzi. Terpène, nitsinda rinini rya phytochemicals izwi mu rumogi, naryo ryerekanye ko ari igice cyingenzi cyingaruka. Ntabwo terpene itanga urumogi uburyohe butandukanye nimpumuro nziza, ariko kandi bigaragara ko ishyigikira izindi molekile z'urumogi mugutanga ingaruka zumubiri nubwonko.
Umurongo w'urufatiro
Urumogi ni igihingwa kitoroshye gifite ubushakashatsi buke bushoboka ku ngaruka zacyo no ku mikoranire y'umubiri w'umuntu - kandi turatangiye kwiga uburyo bwinshi THC, CBD, hamwe n’ibindi bintu by’urumogi bikorana kandi bigahuza na ECS yacu kugirango duhindure uko tubyumva.
Igihe cyo kohereza: Ukwakira-19-2021