Abashakashatsi bavumbuye ko metabolite yambere ya THC ikomeza gukomera hashingiwe kumibare yatanzwe nimiterere yimbeba. Ubushakashatsi bushya bwerekana ko THC metabolite nyamukuru itinda mu nkari no mu maraso bishobora kuba bigikora kandi bikora neza nka THC, niba atari byinshi. Ubu bushakashatsi bushya butera kwibaza byinshi kuruta uko busubiza. Nk’uko ubushakashatsi buherutse gusohoka mu kinyamakuru cya Pharmacology na Experimental Therapeutics bubitangaza, metabolite ya psychoactique ya THC, 11-hydroxy-THC (11-OH-THC), ifite imbaraga zingana cyangwa nyinshi zo mu mutwe kurusha THC (Delta-9 THC).
Ubushakashatsi bwiswe “Kuringaniza Ubusinzi bwa 11-Hydroxy-Delta-9-THC (11-OH-THC) Bifitanye isano na Delta-9-THC,” byerekana uburyo metabolite ya THC igumana ibikorwa. Birazwi neza ko THC isenyuka ikabyara ibintu bishya bishimishije iyo ikora decarboxylates kandi igakora mumubiri wumuntu. Ubushakashatsi bugira buti: "Muri ubu bushakashatsi, twasanze ko metabolite y'ibanze ya THC, 11-OH-THC, igaragaza ibikorwa bingana cyangwa binini kuruta THC mu buryo bw'imbeba y'ibikorwa by'urumogi iyo byakozwe mu buryo butaziguye, ndetse tunareba itandukaniro riri mu nzira z'ubuyobozi, igitsina, imiti ya farumasi, na farumasi." Ati: “Aya makuru atanga ubumenyi bwimbitse ku bikorwa by’ibinyabuzima bya metabolite ya THC, kumenyesha ubushakashatsi bw’urumogi, ndetse no kwerekana uburyo gufata THC na metabolism bigira ingaruka ku ikoreshwa ry’urumogi.”
Ubu bushakashatsi bwakozwe n'itsinda ryaturutse i Saskatchewan, muri Kanada, barimo Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, na Robert B. Laprairie. Muri ubwo bushakashatsi, abashakashatsi bateye imbeba z’abagabo hamwe na 11-hydroxy-THC kandi bareba kandi baniga ingaruka z’iyi metabolite ya THC ugereranije n’ikigo cy’ababyeyi, Delta-9 THC.
Abashakashatsi bakomeje bagaragaza bati: “Aya makuru yerekana ko mu kizamini cy’umurizo cyerekana ububabare, ibikorwa bya 11-OH-THC ni 153% bya THC, naho mu kizamini cya catalepsy, ibikorwa bya 11-OH-THC ni 78% bya THC.
Rero, ubushakashatsi bwerekana ko THC metabolite 11-OH-THC ishobora kugira uruhare runini mubikorwa byibinyabuzima byurumogi. Gusobanukirwa ibikorwa byayo mugihe bitanzwe neza bizafasha gusobanura ubushakashatsi bwinyamaswa nubumuntu. Raporo ivuga ko 11-OH-THC ari imwe muri metabolite ebyiri zibanze zakozwe nyuma yo kunywa urumogi, indi ikaba 11-cyangwa-9-ya-karubasi-THC, idafite imitekerereze ariko ishobora kuguma mu maraso cyangwa inkari igihe kirekire.
Nk’uko ikigo cyo muri Amerika gishinzwe kurwanya no gukumira indwara (CDC) kibitangaza, nko mu myaka ya za 1980, ibizamini by'inkari byibasiye cyane cyane aside 11-cyangwa-delta-9-THC-9-karubasi ya aside (9-carboxy-THC), metabolite ya Delta-9-THC, ikaba ari yo ngingo nyamukuru mu kunywa urumogi.
Raporo yerekana ko nubwo kunywa urumogi ubusanzwe bitanga ingaruka byihuse kuruta kurya urumogi, ingano ya 11-OH-THC yakozwe binyuze mu kurya ni nyinshi kuruta iyo kunywa indabyo z'urumogi. Raporo yerekana ko iyi ari imwe mu mpamvu zituma ibiryo byatewe n'urumogi bishobora kurushaho kuba imitekerereze kandi bigatera urujijo kubatiteguye.
THC Metabolite no Kwipimisha Ibiyobyabwenge
Ibimenyetso byerekana ko urumogi rugira ingaruka kubakoresha mu buryo butandukanye bitewe n'inzira y'ubuyobozi. Ubushakashatsi bwakozwe mu 2021 bwasohotse mu kinyamakuru gihoraho bwerekanye ko ingaruka zo kunywa urumogi ari nyinshi kuruta izo kunywa urumogi bitewe na metabolism ya 11-OH-THC.
Abashakashatsi baranditse bati: "Bioavailable ya THC binyuze mu guhumeka ni 10% kugeza 35%". "Nyuma yo kwinjizwa, THC yinjira mu mwijima, aho ibyinshi muri byo byavanyweho cyangwa bigahinduka muri 11-OH-THC cyangwa 11-COOH-THC, hamwe na THC isigaye hamwe na metabolite yayo yinjira mu maraso. Binyuze mu kanwa, bioavailability ya THC ni 4% kugeza kuri 12% gusa. mugihe mubakoresha karande, birashobora kumara iminsi 5 kugeza 13. ”
Ubushakashatsi bwerekana ko nyuma yigihe kinini ingaruka zo mumitekerereze yurumogi zimaze gushira, metabolite ya THC nka 11-OH-THC irashobora kuguma mumaraso ninkari mugihe kirekire. Ibi bitera imbogamizi kuburyo busanzwe bwo gupima niba abashoferi nabakinnyi bafite ubumuga kubera kunywa urumogi. Kurugero, abashakashatsi bo muri Ositaraliya bagiye bagerageza kumenya igihe urumogi rushobora kubangamira imikorere yo gutwara. Mu rubanza rumwe, Thomas R. Arkell, Danielle McCartney, na Iain S. McGregor bo muri Lambert Initiative muri kaminuza ya Sydney bakoze ubushakashatsi ku ngaruka z'urumogi ku bushobozi bwo gutwara. Iri tsinda ryemeje ko urumogi rwangiza ubushobozi bwo gutwara amasaha menshi nyuma yo kunywa itabi, ariko ubwo bumuga burangira mbere yuko THC metabolite ikurwa mu maraso, metabolite ikomeza kumara ibyumweru cyangwa ukwezi.
Abanditsi banditse bati: "Abarwayi bakoresha ibicuruzwa birimo THC bagomba kwirinda gutwara ndetse n'indi mirimo yita ku mutekano (urugero, imashini ikora), cyane cyane mu gihe cyo kuvura bwa mbere ndetse n'amasaha menshi nyuma ya buri gipimo." Ati: “Nubwo abarwayi batumva ko bafite ubumuga, barashobora kwisuzumisha kuri THC. Byongeye kandi, abarwayi b'urumogi mu by'ubuvuzi ntibasonewe kwipimisha ibiyobyabwenge ku muhanda ndetse n'ibihano bifitanye isano n'amategeko.”
Ubu bushakashatsi bushya kuri 11-OH-THC bwerekana ko hakenewe ubushakashatsi bwinshi kugirango twumve neza uburyo metabolite ya THC igira ingaruka kumubiri wumuntu. Gusa kubwimbaraga zihoraho dushobora guhishura byimazeyo amabanga yibi bintu bidasanzwe.
Igihe cyo kohereza: Werurwe-21-2025